Nuvonic (Hanovia) PharmaLine UV Systems

All PharmaLine reactors use stainless steel 316L / 1.4404 wetted surfaces. The gaskets are EPDM, listed to FDA 21 CFR 177.2600; the six non-ECO variants (D AF, D AF H, PQ AF, PQ AF H, DC PH, DO AF H) are additionally USP Class VI 121°C approved. The full range is catalogued under UV systems.

Variant Overview

D AF and D AF H: Standard and Hygienic Pre-treatment

PharmaLine D AF covers 6 models (0003–0090) in the 115 – 700 W lamp power range. It uses a single low-pressure amalgam lamp with a 12,000-hour life and a standard flanged body for pre-treatment positions where hygienic finish is not critical. D AF H offers the same power range with a tri-clamp hygienic body and an inner surface finish of <0.38 µm for cGMP distribution loops.

PQ AF and PQ AF H: Validated Dose Assurance

The PQ range supplies 5 models (0005–0090) in the 125 – 750 W range. These reactors are third-party biodosimetry validated against the USEPA UV Disinfection Guidance Manual. A dry DVGW UV sensor and UVGuard window allow performance checks against a reference sensor while the system is running; flow and UVT meter inputs enable real-time RED calculations. RS485 Modbus communicates with the plant SCADA. PQ AF uses standard flanges, while PQ AF H uses tri-clamp hygienic construction.

DC PH: Free Chlorine Removal

PharmaLine DC PH uses medium-pressure lamps across 10 models (DC PH 50–500) with a power range of 1.6 – 25.2 kW. It breaks down residual free chlorine (HOCl and OCl⁻) with high-intensity 200–400 nm UV to protect downstream RO and EDI equipment without chemical dosing or media replacement. Lamp life is 8,000 hours, reduced to 4,000 hours on DC PH 250/300. Fluid temperature limits are 1°C – 60°C, or up to 80°C without a wiper.

DO AF H: Post-SIP Ozone Destruction

The DO AF H is built for distribution loops that use ozone for SIP. After the ozone disinfection phase, the reactor is switched on remotely to remove residual ozone before the loop returns to service. It covers 5 models (0001–0020) in the 115 – 700 W range with a 12,000-hour low-pressure amalgam lamp and tri-clamp hygienic body.

ECO: Compact Loop and Point-of-Use Protection

PharmaLine ECO is a compact line for flows of 3.4 – 116 m³/h across models ECO 4 – ECO 125. Power ranges from 90 – 1,080 W using low-pressure amalgam lamps with an expected life of ~9,000 hours. The flow figures are disinfection capacities at a UV dose of 30 mJ/cm² and 98 % T10 at end of lamp life, and may differ with flange connections. The 316L / 1.4404 body is finished to <0.5 µm Ra, with an optional 0.38 µm Ra surface. Operating fluid temperature is 5°C – 40°C, and the reactor tolerates CIP at up to 95°C when the cabinet is electrically isolated.

Certifications

The entire PharmaLine range is CE marked. DC PH is UL listed (E149108); UL listing is an option on PQ AF and PQ AF H. The ECO datasheet lists CE marked and UL.

Applications

D AF is used for standard disinfection at pre-treatment stages of purified water systems. D AF H supplies hygienic tri-clamp disinfection inside GMP distribution loops. PQ AF and PQ AF H provide third-party biodosimetry-validated assurance for critical disinfection or pathogen barriers. DC PH protects downstream EDI systems and RO membranes from residual free chlorine and bio-fouling. DO AF H destroys residual ozone after SIP cycles. The ECO line covers PW and distribution line disinfection, RO/EDI post-treatment protection, inlet microbiological barriers and point-of-use distribution line guarding.

How Mikron Proses Helps

Mikron Proses selects the appropriate PharmaLine variant based on cGMP requirements, process water quality and line position. As Nuvonic distributor, Mikron Proses also handles supply, installation and commissioning. For loop context see the PW/WFI loop sanitization guide and the Nuvonic brand page.

Use the contact page for model selection.