Hamilton CO2NTROL Solid-State Optical Dissolved CO2 Sensor

The Hamilton CO2NTROL is a solid-state optical sensor that measures dissolved CO2 in bioreactors and fermenters by middle-infrared (MIR) absorption. It covers 5 to 1000 mbar (0.5 to 100 %-vol or 7.5 to 1500 mg/L at 101.3 kPa and 25 °C) and, being solid state, has no electrolyte and no consumables. Hamilton describes it as maintenance-free, real-time, in-line control of dissolved CO2 for biopharma cell cultures and fermentations. As one of Hamilton’s distributors in Turkey, Mikron Proses (Üsküdar, Istanbul) supplies CO2NTROL sensors and provides application consulting on sensor selection by bioreactor port length and on ArcAir integration.

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CO2NTROL models

All models share a 12 mm diameter, a PG 13.5 process connection and an Arc RS485 digital output. Only the shaft length differs:

Model	Order code (REF)	Shaft length (a)	Measuring range	Temperature
CO2NTROL 120	10087810-11	120 mm	5 to 1000 mbar (7.5 to 1500 mg/L)	-10 to 140 °C
CO2NTROL 160	10087810-12	160 mm	5 to 1000 mbar (7.5 to 1500 mg/L)	-10 to 140 °C
CO2NTROL 225	10087810-13	225 mm (actual shaft length 215 mm)	5 to 1000 mbar (7.5 to 1500 mg/L)	-10 to 140 °C
CO2NTROL 325	10087810-14	325 mm	5 to 1000 mbar (7.5 to 1500 mg/L)	-10 to 140 °C
CO2NTROL 425	10087810-15	425 mm	5 to 1000 mbar (7.5 to 1500 mg/L)	-10 to 140 °C

The sensor provides no CO2 reading above 60 °C. It is autoclavable and compatible with CIP and SIP, and the wetted parts are stainless steel 1.4435 and EPDM with a surface quality of Ra < 0.4 µm (N5).

Why dissolved CO2 control matters

In biopharma cell cultures and fermentations, Hamilton states that automated control of dissolved CO2 enables increased titer, better batch-to-batch reproducibility and more consistency from R&D to production-scale bioreactors. Because the CO2NTROL is a solid-state sensor with no electrolyte, there are no consumables to replace, and calibration is simple. For standard-gas verification on the bench, Hamilton offers the CO2NTROL Calibration Station (REF 243575).

Combination with other Hamilton sensors

CO2NTROL works with the other Hamilton Arc sensors on the same ArcAir platform, for example the GlucoSense glucose sensor, the InCyte and Dencytee cell density sensors, the EasyFerm Plus pH sensors and the Hamilton dissolved oxygen sensors. Configuration and calibration are covered on the Arc peripherals and ArcAir page.

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Which shaft length fits your bioreactor depends on the port and the immersion depth. Tell us about your bioreactor and we will help you select the right model.